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Updated: Jul 5, 2025

Engineering Antiviral Agents via Surface Plasmon Resonance
Published on: June 14, 2022
Cardiac glycosides from Streblus asper with potential antiviral activity
Qin Ouyang1, Yun-Xuan He1, Yi-Liang Zhang1
1School of Pharmacy, Fudan University, Shanghai, 201203, China.
Abstract:
Ten undescribed cardiac glycosides, strasperosides A-J, together with twelve known analogues, were isolated from Streblus asper Lour. Their structures were elucidated on the basis of spectroscopic analysis, electronic circular dichroism data, and chemical methods. These cardiac glycosides showed diversity in steroid skeleton and sugar moiety. Strasperosides A and B are a pair of unusual stereoisomers featuring different orientation of the lactone motif. Ten cardiac glycosides demonstrated potent antiviral effects on HSV-1 in vitro with the IC50 values from 0.19 ± 0.08 to 1.03 ± 0.25 μM and the therapeutic indices from 66.61 ± 5.08 to 326.75 ± 11.75.
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