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Microfluidic Chips Controlled with Elastomeric Microvalve Arrays
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Programmable fluidic networks on centrifugal microfluidic discs.

Lourdes An Julius1, Sarai M Torres Delgado2, Rohit Mishra3

  • 1Fraunhofer Project Center at Dublin City University (FPC@DCU), Dublin City University, Glasnevin, Dublin 9, Ireland; School of Physical Sciences, Dublin City University, Glasnevin, Dublin 9, Ireland.

Analytica Chimica Acta
|January 14, 2024
PubMed
Summary
This summary is machine-generated.

We developed programmable fluidic networks on centrifugal discs using dissolvable film valves. This innovation reduces manufacturing costs and allows a single disc to perform multiple assays, making diagnostics more accessible.

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Area of Science:

  • Biomedical engineering
  • Microfluidics
  • Laboratory automation

Background:

  • Lab-on-a-Disc (LoaD) platforms offer potential for biomedical diagnostics and lab automation due to their integration capabilities.
  • A key challenge for microfluidic chips is the high manufacturing cost associated with application-specific customization.
  • Programmable fluidic networks are needed to overcome these limitations.

Purpose of the Study:

  • To present novel centrifugal discs featuring programmable fluidic networks.
  • To demonstrate cost-effective and versatile microfluidic solutions for diagnostic applications.

Main Methods:

  • Development of centrifugal discs utilizing dissolvable film valves.
  • Implementation of pulse-actuated dissolvable film valves for sequential reagent release.
  • Utilizing electronic Lab-on-a-Disc (eLoaD) wireless valve arrays for actuating multiple centrifugo-pneumatic dissolvable film valves.

Main Results:

  • A centrifugal disc capable of six sequential reagent releases into one chamber or three releases into two chambers was demonstrated.
  • A disc utilizing the eLoaD system successfully delivered one of eight reagent washes to four reaction chambers.
  • Identical discs were used to show sequential washes in both two and four reaction chambers.

Conclusions:

  • Programmable fluidic networks enable a single disc architecture for diverse assay types, reducing costs and improving integration.
  • This technology offers a lower-cost, more integrated alternative to traditional micro-titre plates and liquid handling robots.
  • The approach facilitates concurrent execution of multiple assays, lowering manufacturing expenses and streamlining supply chains for accessible diagnostics.