Optimizing an exercise training program in pediatric brain tumour survivors: Does timing postradiotherapy matter?

Area of Science:

• Neuroscience
• Oncology
• Rehabilitation Medicine

Background:

• Pediatric brain tumor (PBT) survivors often experience cognitive and motor deficits post-treatment.
• Exercise training (ET) is known to improve outcomes in PBT survivors, but optimal timing remains unclear.

Purpose of the Study:

• To investigate the feasibility and benefits of ET programs based on their timing after radiotherapy in PBT survivors.
• To identify the optimal window for initiating ET to maximize adherence, retention, and positive health outcomes.

Main Methods:

• Retrospective analysis of PBT survivors participating in an ET program.
• Groups categorized by time since radiotherapy completion: <2 years, 2-5 years, and >5 years.
• Repeated measures ANOVA and correlation analyses used to compare feasibility and efficacy indicators.

Main Results:

• The 2-5 year post-radiotherapy group showed optimal adherence (88.5%), retention (100%), and satisfaction.
• Cognitive benefits, including memory recognition and accuracy, decreased with longer time post-radiotherapy.
• Motor function improved across all groups, with bilateral coordination improving earlier and running improving later post-radiotherapy.

Conclusions:

• ET programs should be integrated into routine post-radiotherapy care for PBT survivors, ideally within the first 1-2 years.
• Encouraging ET participation within the first 5 years post-radiotherapy is recommended to maximize benefits.