Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Drug combination choices of 5α-reductase inhibitors and α-blockers in patients with benign prostatic hyperplasia: a study based on the FAERS database.

Frontiers in medicine·2026
Same author

"When Rest Feels Wrong": A Qualitative Study of Rest Intolerance Among Nursing Interns and Implications for Workforce Resilience.

Journal of nursing management·2026
Same author

Comparison of open, laparoscopic, and robot-assisted ileal ureter replacement for long ureteral strictures: a multi-institutional bidirectional cohort study.

World journal of urology·2026
Same author

Cytoreductive radical prostatectomy in patients with high-volume metastatic prostate cancer achieving deep biochemical response to contemporary systemic therapy: a multicentre, prospective cohort study.

BMC medicine·2026
Same author

Robot-Assisted Radical Prostatectomy Using the KangDuo-SR-2000: A Prospective, Multicenter, Single-Arm Clinical Study.

The international journal of medical robotics + computer assisted surgery : MRCAS·2026
Same author

Pathology-Driven Genomic Panels for Personalized Prognostic Stratification and Exploratory Therapeutic Prediction in Clear-Cell Renal Cell Carcinoma with Tumor Thrombus.

Diagnostics (Basel, Switzerland)·2026
Same journal

Engineering Lymphatic Vessels and Lymphoid Microenvironments In Vitro to Investigate Immune Cell Trafficking.

Current opinion in biomedical engineering·2026
Same journal

Next generation technologies for CRISPR-based epigenome and transcriptional modulation.

Current opinion in biomedical engineering·2026
Same journal

Bioengineering gradients for controlled embryo and organ modeling.

Current opinion in biomedical engineering·2026
Same journal

Hyaluronic acid-based models of the brain microenvironment: Challenges and advances.

Current opinion in biomedical engineering·2026
Same journal

Interplay between extracellular matrix mechanics and cell function in mechanobiology.

Current opinion in biomedical engineering·2026
Same journal

Rewriting the epigenome: CRISPR tools for biological discovery and therapeutics.

Current opinion in biomedical engineering·2026
See all related articles

Related Experiment Video

Updated: Jul 5, 2025

Pooled CRISPR-Based Genetic Screens in Mammalian Cells
00:09

Pooled CRISPR-Based Genetic Screens in Mammalian Cells

Published on: September 4, 2019

21.9K

Pooled screening with next-generation gene editing tools.

Liqun Zhou1,2,3,4, Luojia Yang1,2,3,5, Yanzhi Feng1,2,3,4

  • 1Department of Genetics, Yale University School of Medicine, New Haven, CT, USA.

Current Opinion in Biomedical Engineering
|January 15, 2024
PubMed
Summary
This summary is machine-generated.

Pooled screening, utilizing advanced gene editing tools like CRISPR, enables simultaneous examination of genetic variants to understand biological functions and identify therapeutic targets. This technology offers growing opportunities in research across various organisms.

Keywords:
CRISPRCRISPR screenCell engineeringGene editingGene regulation

More Related Videos

Author Spotlight: Finding New Therapeutic Targets for Malignant Peripheral Nerve Sheath Tumor Through Genome-Scale shRNA Screens
09:33

Author Spotlight: Finding New Therapeutic Targets for Malignant Peripheral Nerve Sheath Tumor Through Genome-Scale shRNA Screens

Published on: August 25, 2023

1.2K
Integration of Wet and Dry Bench Processes Optimizes Targeted Next-generation Sequencing of Low-quality and Low-quantity Tumor Biopsies
13:24

Integration of Wet and Dry Bench Processes Optimizes Targeted Next-generation Sequencing of Low-quality and Low-quantity Tumor Biopsies

Published on: April 11, 2016

11.9K

Related Experiment Videos

Last Updated: Jul 5, 2025

Pooled CRISPR-Based Genetic Screens in Mammalian Cells
00:09

Pooled CRISPR-Based Genetic Screens in Mammalian Cells

Published on: September 4, 2019

21.9K
Author Spotlight: Finding New Therapeutic Targets for Malignant Peripheral Nerve Sheath Tumor Through Genome-Scale shRNA Screens
09:33

Author Spotlight: Finding New Therapeutic Targets for Malignant Peripheral Nerve Sheath Tumor Through Genome-Scale shRNA Screens

Published on: August 25, 2023

1.2K
Integration of Wet and Dry Bench Processes Optimizes Targeted Next-generation Sequencing of Low-quality and Low-quantity Tumor Biopsies
13:24

Integration of Wet and Dry Bench Processes Optimizes Targeted Next-generation Sequencing of Low-quality and Low-quantity Tumor Biopsies

Published on: April 11, 2016

11.9K

Area of Science:

  • Genomics
  • Molecular Biology
  • Biotechnology

Background:

  • Pooled screening allows simultaneous analysis of genetic variants in cell populations.
  • It enables systematic investigation of gene function and biological processes.
  • Advances in gene editing and sequencing are expanding its applications.

Purpose of the Study:

  • To review recent advances in pooled screening technologies.
  • To highlight the use of next-generation gene editing tools in pooled screens.
  • To discuss challenges and future directions for pooled screening.

Main Methods:

  • Utilizing pooled cell populations with induced genetic variants.
  • Employing next-generation gene editing tools (e.g., CRISPR).
  • Leveraging advances in sequencing and computational analysis.

Main Results:

  • Pooled screening facilitates the examination of gene function and cellular behavior.
  • CRISPR and related technologies enhance the efficiency and scope of pooled screens.
  • This approach aids in identifying targets for therapeutic interventions and agricultural research.

Conclusions:

  • Pooled screening with advanced gene editing tools is a powerful technology for biological discovery.
  • It holds significant potential for advancements in medicine and agriculture.
  • Continued development is expected to overcome current challenges and expand applications.