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Association between Factor-V Leiden and occurrence of acute myocardial infarction using a large NIS database

Luis Zuniga1, Mitchell Davis2, Mohammad Reza Movahed3,4

  • 1University of Nebraska Medical Center Omaha, NE, USA.

American Journal of Blood Research
|January 15, 2024
PubMed

Insights

Factor V Leiden (FVL) is a genetic condition. This study found no significant association between FVL and acute myocardial infarction (AMI) in individuals over 18 years old.

Area of Science:

  • Genetics
  • Cardiology
  • Thrombosis

Background:

  • Factor V Leiden (FVL) is an inherited thrombophilia.
  • Activated Protein C (APC) resistance is a key feature of FVL.
  • The link between FVL and acute myocardial infarction (AMI) remains debated.

Purpose of the Study:

  • To investigate the association between Factor V Leiden mutation and acute myocardial infarction.
  • To determine if FVL carriers have a higher risk of developing AMI.

Main Methods:

  • Retrospective observational analysis using the Nationwide Inpatient Sample (NIS) database.
  • Utilized ICD-10 codes to identify patients with APC resistance and AMI.
  • Analyzed two populations: 18-40 years and all patients over 18.

Main Results:

  • Univariate analysis showed a slight increase in AMI for FVL patients (18-40 group).
  • Multivariate analysis, adjusted for age and comorbidities, found no significant association between FVL and AMI (OR 1.44, p=0.117).
  • Analysis of the entire population (over 18) also revealed no significant correlation between FVL and AMI.

Conclusions:

  • Factor V Leiden mutation is not associated with an increased risk of acute myocardial infarction.
  • No correlation was found between FVL and AMI in the studied populations over 18.
  • Further research is needed to clarify the relationship between FVL and cardiovascular events.

Keywords:
FVLFactor V LeidenMIactivated protein C resistancedeep venous thrombosismyocardial infarctionprimary hypercoagulable state

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