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Genomics02:02

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Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
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A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
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Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
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Phage Phenomics: Physiological Approaches to Characterize Novel Viral Proteins
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Phenomic Imaging.

Lizhen Lan1, Kai Feng1, Yudan Wu1

  • 1Human Phenome Institute, Fudan University, 825 Zhangheng Road, Pudong New District, Shanghai, 201203 China.

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|January 15, 2024
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Summary
This summary is machine-generated.

Phenomic imaging visualizes human traits across scales, integrating with genomics and metabolomics. This approach aids in understanding complex biological systems and developing novel diagnostics and therapeutics.

Keywords:
GenomicsImagingImmunomicsMetabolomicsPhenomicsProteomicsTranscriptomics

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Area of Science:

  • Multidisciplinary science integrating biology, medicine, and imaging technologies.

Background:

  • Human phenomics studies observable traits influenced by genes, epigenetics, organs, microbiome, diet, and environment.
  • Phenomic imaging captures anatomical, functional, metabolic, and biochemical data across scales, both in vivo and ex vivo.

Purpose of the Study:

  • To review phenomic imaging modalities and their applications in human phenomics.
  • To explore the integration of phenomic imaging with other omics disciplines.

Main Methods:

  • Utilizing diverse imaging techniques to visualize and measure phenotypes.
  • Correlating macro- and micro-phenotypes for a comprehensive understanding.
  • Integrating phenomic imaging data with genomics, transcriptomics, proteomics, immunomics, and metabolomics.

Main Results:

  • Phenomic imaging provides a detailed view of normal and abnormal human traits.
  • Integration with other omics data enhances biological system comprehension.
  • Identified potential for new therapeutic and diagnostic strategies.

Conclusions:

  • Phenomic imaging is essential for deciphering complex human phenomes.
  • Multimodal omics data integration, including phenomic imaging, is key to advancing precision medicine.
  • This integrated approach promises significant breakthroughs in understanding health and disease.