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Simultaneous melanomas in the setting of multiple primary melanomas
Maria Kostaki1, Michaela Plaka2, Aggeliki Befon2
1Department of Plastic Surgery, Microsurgery, Burns and Melanoma Reference Center, General Hospital of Athens G.Gennimatas.
Melanoma Research
|January 15, 2024
Summary
Simultaneous melanomas, diagnosed within one month, represent a significant portion of multiple primary melanomas. These cases show distinct characteristics compared to non-synchronous tumors.
Area of Science:
- Dermatology
- Oncology
- Epidemiology
Background:
- Multiple primary melanomas affect 1-13% of melanoma patients.
- Simultaneous melanomas (diagnosed within 1 month) are less studied than non-synchronous ones.
Purpose of the Study:
- To investigate the epidemiological, clinical, and histological features of simultaneous melanomas.
- To compare simultaneous melanomas with non-synchronous multiple primary melanomas.
Main Methods:
- Retrospective review of melanoma patient registries (2000-2020).
- Identification and comparison of patients with simultaneous versus non-synchronous multiple primary melanomas.
Main Results:
- 3.4% of 2500 melanoma patients had multiple primary melanomas; 40.7% of these had simultaneous melanomas.
- Simultaneous melanoma patients more frequently developed over two tumors.
- Tumor thickness differed significantly between first and second tumors in both groups, but not between simultaneous tumors themselves.
Conclusions:
- Simultaneous melanomas constitute a notable subgroup of multiple primary melanomas.
- Distinct clinical and histological differences may define simultaneous melanomas as a unique category.
