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Related Experiment Video

Updated: Jul 5, 2025

Author Spotlight: Integrating Ultrasound Imaging with Biochemical Markers for Thyroid Disease Diagnosis
05:41

Author Spotlight: Integrating Ultrasound Imaging with Biochemical Markers for Thyroid Disease Diagnosis

Published on: February 9, 2024

632

Functional decoding and meta-analytic connectivity modeling in thyroid-associated ophthalmopathy.

Qidang Duan1, Zhihong Wang2, Wunting Cheung3

  • 1School of Basic Medicine and Life Science, Hainan Medical University, Haikou, 571199, China.

Heliyon
|January 16, 2024
PubMed
Summary

Thyroid-associated ophthalmopathy (TAO) involves altered brain activity in the superior frontal gyrus and cuneus/precuneus, impacting cognitive and emotional functions. These findings highlight the role of working memory deficits in TAO pathophysiology.

Keywords:
ALE meta-analysisSuperior frontal gyrusThyroid-associated ophthalmopathycuneus

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Area of Science:

  • Neuroscience
  • Ophthalmology
  • Endocrinology

Background:

  • Thyroid-associated ophthalmopathy (TAO) is a debilitating orbital disease linked to thyroid dysfunction.
  • Previous neuroimaging studies in TAO patients yielded inconsistent findings regarding brain function.
  • A quantitative meta-analysis is needed to identify consistent patterns of brain abnormalities in TAO.

Purpose of the Study:

  • To identify convergent patterns of abnormal brain function in patients with TAO using a quantitative meta-analysis.
  • To explore the functional connectivity and cognitive/emotional associations of identified brain regions in TAO.

Main Methods:

  • A systematic literature search was conducted across major databases (PubMed, EMBASE, Cochrane, Web of Science).
  • Fifteen eligible studies were included, and peak coordinates were extracted for meta-analysis using activation likelihood estimation (ALE).
  • Task-related meta-analytic connectivity modeling (MACM) was employed to analyze functional connectivity.

Main Results:

  • TAO patients exhibited increased resting-state brain activity in the left superior frontal gyrus (SFG) and decreased activity in the left cuneus/precuneus compared to controls.
  • Functional decoding indicated these regions are associated with cognitive and emotional impairments.
  • MACM analysis revealed significant coactivation in areas including the superior parietal lobule, medial frontal gyrus, and thalamus.

Conclusions:

  • The study highlights the involvement of the SFG and cuneus/precuneus in TAO pathophysiology.
  • Working memory deficits are suggested to play a crucial role in the observed brain function alterations in TAO.