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Artificial Homeostasis Systems Based on Feedback Reaction Networks: Design Principles and Future Promises
Vinay Ambekar Ranganath1, Indrajit Maity1
1Centre for Nano and Material Sciences, Jain (Deemed-to-be University), Jain Global Campus, Bangalore, 562112, Karnataka, India.
Angewandte Chemie (International Ed. in English)
|January 16, 2024
Summary
Feedback-controlled chemical reaction networks (FCRNs) enable synthetic cells to achieve homeostasis. This review explores FCRNs for engineering self-regulating artificial systems across various scales.
Area of Science:
- Systems chemistry
- Chemical biology
- Biophysics
Background:
- Feedback-controlled chemical reaction networks (FCRNs) are crucial for biological processes like cellular signaling and maintaining internal stability via feedback loops (FLs).
- Creating minimalistic synthetic cells with cellular functions is a key goal in systems chemistry, requiring synthetic homeostasis.
Purpose of the Study:
- To review artificial homeostasis systems driven by FCRNs at different length scales (homogeneous, compartmentalized, soft material).
- To highlight FCRNs as essential tools for engineering nonlinear functions and homeostatic systems.
- To emphasize the history and advanced functions of synthetic homeostasis in chemical and material systems.
Main Methods:
- Overview of FCRNs in molecular and supramolecular systems.
- Discussion of existing synthetic homeostasis in chemical and material systems.
- Analysis of self-correcting and regulating properties in artificial systems.
Main Results:
- FCRNs are vital for engineering synthetic cells and achieving homeostasis.
- Biological systems offer insights for designing artificial homeostatic systems.
- FCRNs can be applied across homogeneous, compartmentalized, and soft material systems.
Conclusions:
- Engineering synthetic homeostasis is essential for developing functional synthetic cells.
- FCRNs provide a robust framework for creating artificial systems with self-regulating properties.
- Further research into FCRNs can advance the field of synthetic biology and materials science.
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