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Acinetobacter baumannii infection in intensive care unit: analysis of distribution and drug resistance

Siyang Zhao1, Bing Zhang2, Conghai Liu2

  • 1Department of Clinical Research Center, Dazhou Central Hospital, Dazhou, Sichuan province, China.

Molecular Biology Reports
|January 16, 2024
PubMed
Abstract

Insights

Acinetobacter baumannii infections in intensive care units (ICUs) show increasing isolation and drug resistance, particularly multi-drug resistance. All imipenem-resistant strains carried the OXA-23 gene, highlighting the need for enhanced infection control.

Area of Science:

  • Medical Microbiology
  • Infectious Diseases
  • Intensive Care Medicine

Background:

  • Acinetobacter baumannii (A. baumannii) infections are a growing concern in intensive care units (ICUs), leading to increased morbidity and mortality.
  • Rising isolation and drug resistance rates necessitate analysis of A. baumannii characteristics in ICUs.

Purpose of the Study:

  • To analyze the distribution, drug resistance, and influencing factors of A. baumannii in ICU patients.
  • To provide data for effective infection prevention and clinical treatment strategies.

Main Methods:

  • Retrospective analysis of A. baumannii infected patients in the ICU from January 2020 to December 2021.
  • Bacterial culture, drug sensitivity testing, and drug-resistant gene detection (OXA-23) were performed on isolated strains.

Main Results:

  • A total of 197 A. baumannii strains were isolated in 2021, an increase from 2020. Specimens were primarily from lower respiratory tract secretions.
  • Multi-drug resistance in A. baumannii isolates remains high, with significant increases in resistance to tobramycin, gentamicin, and trimethoprim-sulfamethoxazole in 2021 compared to 2020.
  • All imipenem-resistant A. baumannii strains harbored the OXA-23 gene.

Conclusions:

  • Clinical antibiotic use should be guided by bacterial resistance patterns.
  • Strengthening hospital infection prevention and control measures, including disinfection and isolation, is crucial to reduce cross-infection risks.
Keywords:
Acinetobacter baumanniiDrug resistanceICU

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