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Updated: Jul 5, 2025

Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients
Published on: March 1, 2024
Atopic Dermatitis Severity and Risk for Psoriasis: A Nationwide Population-Based Study
Hyun Ji Lee1, Yong Jun Hong2, Kyung Do Han3
1Department of Dermatology, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea, o0or5r5r@gmail.com.
Introduction:
As research on the role of the Th17/IL-23 pathway gains importance, the relationship between atopic dermatitis (AD) and psoriasis is becoming elucidated.
Objective:
The objective of this study wasto evaluate whether AD and its severity affect the risk for psoriasis.
Methods:
This retrospective population-based study used the database from the 2009 National Health Insurance Services-Health Screening Cohort in Korea. A total of 3,957,922 adult subjects were included and observed until 2018. The primary outcome was newly diagnosed psoriasis.
Results:
After adjusting for possible confounding factors, the moderate-to-severe AD group had the highest hazard ratio (HR) for psoriasis (HR = 2.50; 95% confidence interval (CI), 2.40-2.61), followed by the mild AD group (HR = 2.31; 95% CI: 2.19-2.44) compared with the non-AD group during a median 8.11 ± 1.19 years of follow-up.
Limitations:
It is difficult to define AD, which is not standardized, using a claims database and exclude patients who were misdiagnosed with AD.
Conclusion:
Patients with severe AD showed an increased risk for psoriasis compared to controls, and the risk for psoriasis was increased according to AD severity. This suggests that psoriasis and AD could share inflammatory, immune, and genetic features.
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