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Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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Disorders of Hemostasis01:24

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Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
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Changes in Skin Color: Clinical Perspectives01:14

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The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
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The autonomic nervous system (ANS) is an intricate network of nerves that controls functions such as the regulation of heart rate, digestion, and blood pressure regulation. When this system malfunctions, it can lead to various disorders that affect multiple bodily functions. One common feature of many autonomic disorders is the involvement of smooth blood vessels, which play a crucial role in regulating blood flow throughout the body.
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Capillary Beds01:20

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Capillary beds are networks of tiny blood vessels that play a crucial role in the circulatory system. These beds are where the exchange of gases, nutrients, and waste products occurs between the blood and surrounding tissues. Each capillary bed consists of numerous capillaries, which are the smallest blood vessels in the body, typically only one cell-thick. This thinness allows for the efficient diffusion of substances.
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Capillaries and Their Types01:20

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Microcirculation disorders of the skin.

Stine Lutze1, Thea Westphal1, Michael Jünger1

  • 1Clinic and Polyclinic for Skin and Venereal Diseases, University Hospital Greifswald, Greifswald, Germany.

Journal Der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
|January 16, 2024
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Summary

Skin microcirculation changes are common in many diseases, not just skin conditions. Investigating these changes is crucial for diagnosing and managing systemic sclerosis and peripheral hemodynamic disorders like PAD and CVI.

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Area of Science:

  • Dermatology
  • Vascular Biology
  • Systemic Autoimmune Diseases

Background:

  • Cutaneous microcirculation alterations are observed in numerous systemic and dermatological diseases.
  • While some changes are benign (e.g., psoriasis, atopic eczema), others indicate serious microangiopathies.
  • Systemic sclerosis exemplifies a disease where microcirculatory dysfunction has severe, multi-organ consequences.

Purpose of the Study:

  • To highlight the diagnostic and prognostic significance of cutaneous microcirculation investigations.
  • To underscore the role of microangiopathies in systemic sclerosis.
  • To emphasize the importance of understanding microcirculatory disturbances in peripheral arterial disease (PAD) and chronic venous insufficiency (CVI) for therapeutic guidance.

Main Methods:

  • Review of existing literature on skin microcirculation in various diseases.
  • Analysis of the role of microangiopathy in systemic sclerosis pathogenesis and progression.
  • Examination of microcirculatory assessments in managing PAD and CVI.

Main Results:

  • Skin microcirculation changes are valuable indicators across a spectrum of diseases.
  • Microangiopathy is a key feature of systemic sclerosis, impacting diagnosis and prognosis.
  • Microcirculatory assessment aids in therapy and monitoring of PAD and CVI.

Conclusions:

  • Investigating skin microcirculation is essential for diagnosing, prognosing, and managing systemic sclerosis.
  • Understanding microcirculatory disturbances is critical for effective treatment and monitoring of peripheral hemodynamic disorders.
  • Cutaneous microcirculation serves as a vital window into systemic health and disease progression.