[Comparative study of the frequency of HLA antigens in diffuse toxic goiter and autoimmune thyroiditis]

Class I HLA antigens were determined in 42 patients with diffuse toxic goiter (DTG), 31 patients with autoimmune thyroiditis (AT) and in 71 donors. A degree of association of antigen and disease (R) and difference in the frequency of some HLA antigen bearing in the groups of patients and healthy persons were revealed. Positive association of DTG with antigens A1, A3, B8, haplotype A1-B8 and AT with A1 and B35 was established. The bearing of B13 antigen in DTG and A11 in AT was a protective factor in the development of the above diseases. A study of the comparative distribution of HLA antigens in DTG and AT showed immunogenetic heterogeneity of these diseases, determining perhaps difference in the immune response of DTG and AT patients.