[Experimental research on the chronic inhalational toxicity of chloracetophon]

The chronic inhalational toxicity of chloracetophon was studied on 24 albino Wistar rats, with concentrations 20 mg X m-3. The animal were exposed 4 hours/daily, 5 days/weekly, for 90 days. Integral, biochemical, histological and electron-microscopic methods were used for the evaluation of the toxic effect of the preparation. The results reveal metabolic and structural alterations in the organs studied, better manifested in liver as compared with the lungs. A provisional MAC for chloracetophon is proposed on the base of the complex study carried out, being 0.1 mg X m-3.