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[Nephrology: what's new in 2023]
Sophie De Seigneux1, Fadi Haidar1, David Jaques1
1Service de néphrologie, Département de médecine, Hôpitaux universitaires de Genève, 1211 Genève 14.
Revue Medicale Suisse
|January 17, 2024
Summary
New molecules like sparsentan and budesonide show promise for IgA nephropathy. Sodium-glucose cotransporter 2 (SGLT2) inhibitors offer nephroprotection for acute kidney injury and renal transplant patients.
Area of Science:
- Nephrology
- Pharmacology
- Nephrology Therapeutics
Context:
- Proteinuric IgA nephropathy presents a significant clinical challenge.
- Acute kidney injury (AKI) secondary to heart failure requires effective management strategies.
- Renal transplant recipients often face risks of graft dysfunction.
Purpose:
- To review emerging therapeutic options for proteinuric IgA nephropathy.
- To evaluate the role of SGLT2 inhibitors in nephroprotection and AKI.
- To assess the efficacy of different dialysis modalities and supportive treatments in renal patients.
Summary:
- Sparsentan and budesonide demonstrate potential for treating proteinuric IgA nephropathy.
- Sodium-glucose cotransporter 2 (SGLT2) inhibitors are highlighted for their nephroprotective effects in AKI and post-transplant settings.
- High volume hemodiafiltration shows improved survival over hemodialysis, while reduced dialysate temperature offers no hemodynamic benefit. Sodium bicarbonate does not appear to protect renal function in transplant patients.
Impact:
- Identifies promising agents for IgA nephropathy, offering new treatment avenues.
- Highlights the expanding role of SGLT2 inhibitors in kidney disease management.
- Provides insights into optimizing dialysis strategies and supportive care for renal patients.
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