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Peptide Self-assembly: From Ordered to Disordered.

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Peptide self-assembly creates transient, disordered structures. Researchers precisely control these structures, from ordered to disordered states, enabling new biomolecular materials.

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Area of Science:

  • Biomolecular self-assembly
  • Supramolecular chemistry
  • Materials science

Background:

  • Nature utilizes biomolecular self-assembly for complex functions, forming ordered (e.g., DNA) and disordered structures (e.g., nucleolus).
  • Disordered structures offer adaptability but are often metastable and challenging to stabilize.
  • Peptide self-assembly (PSA) offers a simpler model than proteins for studying multiscale self-assembly, especially disordered states.

Approach:

  • Investigating the dynamic evolution of peptide supramolecular systems, from ordered to disordered.
  • Exploring mechanisms for precise control over peptide self-assembly processes.
  • Studying liquid-liquid phase separation (LLPS) in multistep self-assembly.

Key Points:

  • Discovered transient, droplet-like disordered structures during peptide self-assembly.
  • Demonstrated that metastable liquid droplets can be modulated to form ordered structures.
  • Developed novel disordered solid glasses from peptide and amino acid derivatives.

Conclusions:

  • Peptide self-assembly provides a versatile platform for creating tunable supramolecular structures.
  • Precise control over PSA enables the generation of both ordered and disordered materials.
  • Biologically derived molecules can be used to create sustainable glassy materials.