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Folic Acid and Diabetic Foot Ulcers.
Elisavet E Pyrgioti1, Nikolaos D Karakousis2, Petros N Georgakopoulos3
1Pharmacist, Private Practice, Athens, Greece.
The International Journal of Lower Extremity Wounds
|January 17, 2024
Summary
Diabetic foot ulcers (DFUs) are linked to lower folic acid (FA) levels. Preliminary evidence suggests FA may improve DFU healing, highlighting the need for dietary FA assessment and further research.
Area of Science:
- Diabetology
- Nutritional Science
- Wound Healing Research
Background:
- Diabetic foot ulcers (DFUs) represent a significant cause of morbidity in diabetic patients.
- Low levels and intake of folic acid (FA) are observed in individuals with DFUs compared to controls.
Purpose of the Study:
- To review the potential role of folic acid (FA) in the context of diabetic foot ulcers (DFUs).
- To explore the implications of dietary FA intake for DFU management and prevention.
Main Methods:
- This study is a narrative mini-review.
- It synthesizes existing literature on folic acid levels, intake, and DFU healing.
Main Results:
- Individuals with DFUs show lower folic acid levels and daily intake.
- Preliminary evidence indicates that folic acid administration may aid in DFU healing.
Conclusions:
- Regular assessment of dietary folic acid intake could be important for reducing or preventing DFUs.
- Further research is necessary to draw definitive conclusions and establish recommendations regarding folic acid supplementation for DFUs.
