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[Correlation between plasma concentration of heparin and biological response determined by 2 APTT reagents of
Among 56 patients with elevated thromboembolic risk, subject to intravenous infusion of heparin, we have determined the relation between hematic concentration of heparin and activated partial thromboplastin time (APTT), surveyed by two reagents with different sensitivity. The obtained results shown a very good correspondence without significant differences between the APTT reagents used, especially inside the therapeutic range. Otherwise a good correlation is demonstrated between methods, relative to two different chromogenic substrates, applied to heparin determination.
Among 56 patients with elevated thromboembolic risk, subject to intravenous infusion of heparin, we have determined the relation between hematic concentration of heparin and activated partial thromboplastin time (APTT), surveyed by two reagents with different sensitivity. The obtained results shown a very good correspondence without significant differences between the APTT reagents used, especially inside the therapeutic range. Otherwise a good correlation is demonstrated between methods, relative to two different chromogenic substrates, applied to heparin determination.