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The role of ADAR1 through and beyond its editing activity in cancer

Yue Jiao1, Yuqin Xu1, Chengbin Liu1

  • 1School of Basic Medicine Sciences, Weifang Medical University, Weifang, 261053, China.

Cell Communication and Signaling : CCS
|January 17, 2024
PubMed

Insights

Adenosine-to-inosine (A-to-I) RNA editing, primarily by ADAR1, is crucial in cancer. Understanding ADAR1

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • Adenosine-to-inosine (A-to-I) RNA editing is a widespread post-transcriptional modification in mammals.
  • This RNA editing plays a significant role in various diseases, notably cancer.
  • Adenosine deaminases acting on RNA (ADARs), particularly ADAR1, are key enzymes in this process.

Purpose of the Study:

  • To review the current understanding of A-to-I editing and ADARs in cancer.
  • To elucidate the multifaceted roles of ADAR1 in cancer pathogenesis, considering both editing-dependent and independent mechanisms.
  • To summarize factors influencing ADAR1 expression and activity in the context of cancer.

Main Methods:

  • Literature review focusing on A-to-I editing and ADAR1 in cancer research.
  • Analysis of editing-dependent and independent functions of ADAR1.
  • Summary of regulatory factors affecting ADAR1 in cancer.

Main Results:

  • ADAR1 is a major driver of A-to-I editing in cancer.
  • ADAR1 influences cancer through mechanisms involving RNA editing and other cellular processes.
  • Expression and activity of ADAR1 in cancer are modulated by various factors.

Conclusions:

  • ADAR1's complex roles in cancer necessitate further investigation for therapeutic development.
  • Targeting ADAR1 may offer novel strategies for cancer treatment.
  • A comprehensive understanding of ADAR1 regulation is crucial for its clinical application.
Keywords:
ADAR1CancerCancer therapyRNA editingRNA editing-independent

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