Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Gastrulation

Gastrulation

Gastrulation establishes the three primary tissues of an embryo: the ectoderm, mesoderm, and endoderm. This developmental process relies on a series of intricate cellular movements, which in humans transforms a flat, “bilaminar disc” composed of two cell sheets into a three-tiered structure. In the resulting embryo, the endoderm serves as the bottom layer, and stacked directly above it is the intermediate mesoderm, and then the uppermost ectoderm. Respectively, these tissue strata...

Determination

Determination

During embryogenesis, cells become progressively committed to different fates through a two-step process: specification followed by determination. Specification is demonstrated by removing a segment of an early embryo, “neutrally” culturing the tissue in vitro—for example, in a petri dish with simple medium—and then observing the derivatives. If the cultured region gives rise to cell types that it would normally generate in the embryo, this means that it is specified. In...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

5' UTR length shapes alternative N-terminal protein isoforms across cancers and in rare disease.

EMBO reports·2026

Same author

Deep Learning-Assisted Evaluation of Laryngeal Mobility in a Rat Model.

bioRxiv : the preprint server for biology·2026

Same author

5' UTR length regulates alternative N-terminal protein isoform production in health and disease.

bioRxiv : the preprint server for biology·2026

Same author

A novel inhaled anesthesia technique for concurrent direct laryngoscopy in rats.

Animal models and experimental medicine·2025

Same author

RNase MRP subunit composition and role in 40S ribosome biogenesis.

Nature structural & molecular biology·2025

Same author

Immune impacts of fire smoke exposure.

Nature medicine·2025

Same journal

MetaboNet-Bench: A Multi-modal Benchmark for Glucose Forecasting in Type 1 Diabetes.

ArXiv·2026

Same journal

A Positron Range Correction with Texture Preservation Framework in PET Imaging.

ArXiv·2026

Same journal

Automated optimization of force field parameters against ensemble-averaged measurements with Bayesian Inference of Conformational Populations.

ArXiv·2026

Same journal

Droplet Fusion as a Relaxation Process: Comparison with Shape Recovery of Newtonian and Viscoelastic Droplets.

ArXiv·2026

Same journal

Ridge-filter crosstalk in conformal proton FLASH planning: dependence on beamlet pitch and iterative mitigation.

ArXiv·2026

Same journal

Electrochemical DNA Hairpin Sensors for Differentiating Small Molecule Intercalation from Minor Groove Binding.

ArXiv·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jul 5, 2025

Surgical Size Reduction of Zebrafish for the Study of Embryonic Pattern Scaling

Surgical Size Reduction of Zebrafish for the Study of Embryonic Pattern Scaling

Published on: May 3, 2019

Scale invariance in early embryonic development.

Miloš Nikolić^1,2, Victoria Antonetti^1,3, Feng Liu^2,3

¹Joseph Henry Laboratories of Physics and Princeton University, Princeton NJ 08544 USA.

|January 18, 2024

Summary

This summary is machine-generated.

Fruit fly body plan gene expression scales with embryo size, revealing precise positional information. This suggests the genetic network possesses scale invariance, impacting developmental biology research.

More Related Videos

Experimental Manipulation of Body Size to Estimate Morphological Scaling Relationships in Drosophila

Experimental Manipulation of Body Size to Estimate Morphological Scaling Relationships in Drosophila

Published on: October 1, 2011

Tracking Morphogenetic Tissue Deformations in the Early Chick Embryo

Tracking Morphogenetic Tissue Deformations in the Early Chick Embryo

Published on: October 17, 2011

Related Experiment Videos

Last Updated: Jul 5, 2025

Surgical Size Reduction of Zebrafish for the Study of Embryonic Pattern Scaling

Surgical Size Reduction of Zebrafish for the Study of Embryonic Pattern Scaling

Published on: May 3, 2019

Experimental Manipulation of Body Size to Estimate Morphological Scaling Relationships in Drosophila

Experimental Manipulation of Body Size to Estimate Morphological Scaling Relationships in Drosophila

Published on: October 1, 2011

Tracking Morphogenetic Tissue Deformations in the Early Chick Embryo

Tracking Morphogenetic Tissue Deformations in the Early Chick Embryo

Published on: October 17, 2011

Area of Science:

Developmental biology
Genetics
Systems biology

Background:

The fruit fly (Drosophila melanogaster) serves as a model organism for studying fundamental principles of animal development.
Establishing the body plan relies on precise spatial gene expression patterns.
Understanding how these patterns relate to embryo size is crucial for developmental mechanisms.

Purpose of the Study:

To investigate the relationship between gene expression patterns and fruit fly embryo size.
To determine if gene expression patterns exhibit scale invariance.
To explore the mathematical implications of scale invariance in developmental gene networks.

Main Methods:

Analysis of spatial gene expression patterns in fruit fly embryos of varying sizes.
Quantitative measurement of positional markers and graded expression profiles.
Information-theoretic decomposition of positional information.

Main Results:

Spatial patterns of key developmental genes scale precisely with embryo length.
Positional markers show absolute positions proportional to embryo length with high accuracy (>99%).
All positional information derived from gene expression relates to scaled position, not absolute embryo size.

Conclusions:

The fruit fly's genetic network governing body plan determination exhibits scale invariance.
This scale invariance implies a deeper mathematical property within the network dynamics, potentially involving a zero mode.
Findings provide a new framework for understanding developmental robustness and scaling in biological systems.