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Aptamer Renaissance for Neurochemical Biosensing
Annina Stuber1, Nako Nakatsuka1
1Laboratory for Biosensors and Bioelectronics, ETH Zürich, 8092 Zürich, Switzerland.
ACS Nano
|January 18, 2024
Summary
Aptamers offer a promising solution for neurochemical biosensing by overcoming nonspecific binding. This advancement in aptamer technology could significantly improve brain function monitoring and diagnostics.
Area of Science:
- Neuroscience
- Biotechnology
- Materials Science
Background:
- Monitoring neurotransmitters is essential for understanding brain function and advancing human health.
- Current neurochemical biosensing methods face limitations in precision and real-world application.
Purpose of the Study:
- To explore the potential of aptamers integrated into electronic affinity platforms for improved neurochemical biosensing.
- To highlight the importance of aptamer characterization for functional biosensor development.
Main Methods:
- Focus on label-free affinity platforms: field-effect transistors and nanopores.
- Utilized well-characterized structure-switching aptamers to mitigate nonspecific binding.
Main Results:
- Demonstrated that aptamers can overcome nonspecific binding, a major hurdle in biosensor translation.
- Showcased the integration of aptamers with micro- to nanoscale electronic platforms.
Conclusions:
- Aptamer-based biosensors hold significant potential for revolutionizing neuroscience diagnostics.
- Further characterization of aptamer thermodynamics and target binding is crucial for clinical translation.
