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Updated: Jul 5, 2025

Chemoselective Modification of Viral Surfaces via Bioorthogonal Click Chemistry
Published on: August 19, 2012
Synthesis of Original Cyclic Dinucleotide Analogues Using the Sulfo-click Reaction
Romain Amador1, Jean-Jacques Vasseur1, Gabriel Birkuš2
1IBMM, Université de Montpellier, CNRS, ENSCM, 1919 route de Mende, 34095 Montpellier, France.
Abstract:
The stimulator of interferon genes (STING) protein plays a crucial role in the activation of the innate immune response. Activation of STING is initiated by cyclic dinucleotides (CDNs) which prompted the community to synthesize structural analogues to enhance their biological properties. We present here the synthesis and biological evaluation of four novel CDN analogues composed of an N-acylsulfonamide linkage. These CDNs were obtained in high overall yields via the sulfo-click reaction as a key step.
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