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Fertility Preservation Through Oocyte Vitrification: Clinical and Laboratory Perspectives

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Testing an Evidence-Based Self-Help Program for Infertility-Related Distress: Protocol for a Randomized Controlled

Jennifer L Gordon¹, Megan M L Poulter¹, Ashley A Balsom¹

¹Department of Psychology, University of Regina, Regina, SK, Canada.

JMIR Research Protocols

|January 18, 2024

Summary

This study tested a new mobile app intervention for infertility distress. The app significantly improved mental health and quality of life for individuals experiencing infertility.

Keywords:

anxiety cognitive-behavior therapy depression infertility infertility-related distress mHealth

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Area of Science:

Reproductive Health
Mental Health
Digital Health Interventions

Background:

Infertility affects 1 in 6 couples, disproportionately burdening women psychologically.
Existing psychological interventions for infertility distress show limited effectiveness.
Mobile health interventions offer a scalable solution for managing infertility-related mental health challenges.

Purpose of the Study:

To evaluate a novel 7-week, mobile app-based self-help intervention for infertility-related distress.
To compare the efficacy of the intervention against a waitlist control group in a randomized controlled trial.
To assess improvements in fertility quality of life, depressive symptoms, anxiety, and relationship quality.

Main Methods:

A randomized controlled trial involving 170 individuals in Canada and the US.
Intervention group received a 7-week video-based self-help program via mobile app; control group received treatment-as-usual.
Primary outcome: fertility quality of life. Secondary outcomes: depressive/anxious symptoms, relationship quality, healthcare use, diagnosed mood/anxiety disorders.
Assessments conducted pre-intervention, post-intervention, and bi-weekly for 16 weeks post-intervention.

Main Results:

The intervention is expected to be more effective than treatment-as-usual in improving mental health parameters.
Anticipated reduction in healthcare utilization for mental and reproductive health concerns.
Positive effects are expected to be more pronounced in individuals with lower baseline quality of life.

Conclusions:

The mobile app intervention shows promise for effectively reducing psychological distress in individuals with infertility.
Successful outcomes could support the widespread adoption of this digital tool.
This intervention addresses a critical unmet need for accessible mental health support in reproductive medicine.