IGF-1 Levels Increase during an Immune but Not an Oxidative Challenge in an Avian Model, the Japanese Quail

AbstractInsulin-like growth factor 1 (IGF-1) is positively linked with growth and reproduction but negatively linked with survival, so a potential role of IGF-1 in modulating life history trade-offs has been proposed. However, the underlying mechanisms of the negative link between IGF-1 and survival are not yet clear, and oxidative stress has been proposed as a candidate. Immune activation is one important source of oxidative stress, and both immune activation and oxidative stress are known to reduce survival. We experimentally administrated an immune or oxidative insult to Japanese quails to evaluate whether oxidative stress is a proximate cost of holding elevated IGF-1 levels during a life challenge (e.g., infection, intoxication). IGF-1 levels increased in the presence of the immune insult, but they were not affected by the oxidative insult. Hence, IGF-1 may be linked to the survival costs of activating an immune response, but oxidative stress might not be directly involved as an underlying mechanism.