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Extraction Process Optimization of Curcumin from Curcuma xanthorrhiza Roxb. with Supercritical Carbon Dioxide Using
Sutarsi1, Pundhi T Jati1, Diano Wiradiestia1
1Department of Chemical Engineering, Institut Teknologi Sepuluh Nopember, Surabaya 60111, Indonesia.
ACS Omega
|January 19, 2024
Summary
Supercritical carbon dioxide extraction efficiently recovered curcumin from Javanese turmeric (Curcuma xanthorrhiza). Optimized conditions yielded 10.4% extraction and 3.2% curcumin recovery, confirming the method
Area of Science:
- Phytochemistry
- Natural Product Extraction
- Chemical Engineering
Background:
- Curcuma xanthorrhiza Roxb. (Javanese turmeric) is a medicinal plant rich in curcumin.
- Traditional uses of Javanese turmeric highlight its therapeutic potential.
- Curcumin, a key phenolic compound, possesses various bioactive properties.
Purpose of the Study:
- To optimize supercritical carbon dioxide extraction of curcumin from Curcuma xanthorrhiza.
- To investigate the impact of temperature, pressure, and CO2 flow rate on extraction yield and curcumin recovery.
- To determine the optimal parameters for efficient curcumin isolation.
Main Methods:
- Supercritical carbon dioxide (SC-CO2) extraction with ethanol as a cosolvent.
- Box-Behnken design (BBD) for experimental planning.
- Response surface methodology (RSM) for optimization.
- Fourier transform infrared (FTIR) and scanning electron microscopy (SEM) analyses.
Main Results:
- Optimal extraction conditions: 40 °C, 25 MPa, and 5.34 mL/min CO2 flow rate.
- Achieved maximum extraction yield of 10.4% and curcumin recovery of 3.2%.
- FTIR analysis showed reduced functional groups in residue; SEM confirmed cell disruption by high pressure.
Conclusions:
- Supercritical CO2 extraction is effective for isolating curcumin from Javanese turmeric.
- Optimized parameters significantly enhance extraction yield and recovery.
- High-pressure SC-CO2 facilitates cell disruption, improving extraction efficiency.
