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Updated: Jul 5, 2025
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Published on: December 20, 2021
A multiple cancer cell optical biosensing metastructure realized by CPA
Jia-Hao Zou1, Jun-Yang Sui1, You-Ran Wu1
1College of and Optical Engineering & College of Flexible Electronics (Future Technology), Nanjing University of Posts and Telecommunications, Nanjing, 210023, China. hanlor@163.comor.
This study introduces a novel optical biosensing metastructure using graphene and coherent perfect absorption (CPA) for sensitive cancer cell detection. The biosensor demonstrates a strong correlation between refractive index and absorption frequency, enabling precise analysis.
Area of Science:
- Photonics and Nanotechnology
- Biomedical Engineering
- Materials Science
Background:
- Metamaterials offer unique light-matter interaction properties.
- Optical biosensors are crucial for early disease detection.
- Graphene enhances optical and sensing capabilities.
Purpose of the Study:
- To develop a one-dimensional optical biosensing metastructure (OBM) utilizing coherent perfect absorption (CPA).
- To demonstrate the OBM's capability for sensitive refractive index (RI) detection and multiple cancer cell identification.
- To investigate the performance metrics including sensitivity, figure of merit, and detection limit.
Main Methods:
- Fabrication of a 1D optical biosensing metastructure with graphene layers.
- Operation in the transverse electric mode utilizing coherent perfect absorption (CPA).
- Analysis of the linear relationship between RI and absorption peak frequency, and adjustment of detection range via phase difference control.
Main Results:
- A strong linear fit (R-square up to 1) between RI and absorption peak frequency was observed.
- The OBM successfully detected cancer cells within specific ranges (1.34-1.355 and 1.658-1.662).
- Achieved high performance metrics: quality factor (6.9 × 10^4), figure of merit (1.2 × 10^4 RIU^-1), low detection limit (3.6 × 10^-6 RIU), and sensitivity (26.57 THz RIU^-1).
Conclusions:
- The developed OBM based on CPA offers a highly sensitive and efficient platform for biosensing.
- The metastructure enables precise detection of subtle RI changes, crucial for cancer cell identification.
- This technology holds significant potential for widespread application in the biomedical field and advancing CPA research.
