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Related Concept Videos

Arteries of the Lower Limbs01:24

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Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
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Indirect structural changes and reduced controllability after temporal lobe epilepsy resection.

Andrew Janson1, Lucas Sainburg1,2, Behnaz Akbarian1,2

  • 1Department of Radiology and Radiological Sciences, Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

Epilepsia
|January 19, 2024
PubMed
Summary
This summary is machine-generated.

Mesial temporal resection for temporal lobe epilepsy (TLE) causes widespread brain network changes beyond the disconnection site. Average regional controllability (ARC) effectively measures these dynamic functional alterations, aiding in understanding post-surgical outcomes.

Keywords:
diffusion imagingepilepsy surgeryimagingmagnetic resonancenetwork control theory

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Area of Science:

  • Neuroscience
  • Neurology
  • Network Science

Background:

  • Temporal lobe epilepsy (TLE) is a neurological disorder often treated with surgery.
  • Mesial temporal resection aims to disconnect the seizure focus.
  • Understanding the network-wide functional consequences of this disconnection is crucial.

Purpose of the Study:

  • To investigate network-wide alterations in brain dynamics after TLE surgery.
  • To utilize average regional controllability (ARC) to characterize functional changes.
  • To correlate structural disconnections with dynamic brain network alterations.

Main Methods:

  • Diffusion-weighted imaging (DWI) and tractography were used to create structural connectomes.
  • 27 patients with drug-resistant unilateral mesial TLE were studied before and after amygdalohippocampectomy.
  • Node strength and ARC were compared pre- and post-surgery, analyzing direct and indirect edge changes.

Main Results:

  • Significant postsurgical changes in node strength and ARC were observed around the resection zone.
  • ARC detected functional changes in distant brain regions (ipsilateral occipital lobe) linked to indirect network alterations.
  • Hub nodes (thalamus, putamen, insula, precuneus) facilitated these indirect changes.

Conclusions:

  • Mesial temporal resection induces widespread structural and functional brain changes beyond simple disconnection.
  • Dynamic controllability measures like ARC can effectively characterize these complex network alterations.
  • These findings may help predict seizure recurrence and cognitive changes post-surgery.