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[Evaluation of the effect of obsidan in essential hypertension patients with different types of circulation]

O A Goloshchapov, N N Pribylova, L N Kotova

    Terapevticheskii Arkhiv
    |January 1, 1986
    PubMed

    Insights

    Propranolol, a beta-blocker, primarily slowed heart rate in essential hypertension patients. While some experienced improved cardiac function, a significant portion showed negative inotropic effects, impacting myocardial contractility.

    Area of Science:

    • Cardiology
    • Pharmacology

    Background:

    • Essential hypertension is a common cardiovascular condition.
    • Understanding the central hemodynamic effects of beta-blockers is crucial for patient management.

    Purpose of the Study:

    • To investigate the impact of propranolol on central hemodynamics in patients with essential hypertension.

    Main Methods:

    • Polycardiography was used to assess central hemodynamics.
    • The study included 90 patients diagnosed with essential hypertension.

    Main Results:

    • 83% of patients experienced a negative chronotropic effect from propranolol; 17% showed an increased heart rate.
    • Negative inotropic effects were observed in 42% of hyperkinetic patients and 37.5% of eu-/hypokinetic patients.
    • Improved myocardial contractility (increased cardiac output, stroke volume, indices; decreased peripheral resistance) was noted in 24.4% of all patients.

    Conclusions:

    • Propranolol exhibits varied effects on central hemodynamics in essential hypertension.
    • The drug's chronotropic and inotropic effects depend on the patient's hemodynamic type.
    • While beneficial effects on contractility were seen in some, adverse effects are also notable.

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