Multifunctional Nanoplatform for Single NIR Laser-Regulated Efficient PDT/PTT/Chemotherapy

Area of Science:

• Biomedical Engineering
• Nanotechnology
• Oncology

Background:

• Combination therapy offers advantages in cancer treatment but faces challenges with complex operations and systemic side effects.
• Current combination therapies often require multiple stimuli, complicating treatment and potentially reducing efficacy.

Purpose of the Study:

• To design a single near-infrared (NIR) light-regulated nanoplatform for combined photothermal, photodynamic, and chemotherapy.
• To develop a versatile platform for enhanced antitumor efficacy with simplified operation and reduced side effects.

Main Methods:

• Self-assembly of a reactive oxygen species (ROS)-sensitive prodrug (DOX-T-Link, DTD), human serum albumin (HSA), and IR780 into nanoparticles.
• Utilizing 808 nm laser irradiation to trigger ROS generation and photothermal effects for combined therapy.
• Investigating *in vitro* and *in vivo* antitumor efficacy of the developed nanoplatform.

Main Results:

• The nanoplatform successfully integrated photothermal, photodynamic, and chemotherapy triggered by a single NIR laser.
• ROS generated upon laser irradiation initiated both photodynamic therapy and drug release (chemotherapy).
• Demonstrated significant antitumor efficacy in both *in vitro* and *in vivo* experiments.

Conclusions:

• The developed NIR light-regulated nanoplatform offers a promising strategy for effective cancer treatment.
• This single-light-triggered combination therapy enhances therapeutic outcomes and simplifies treatment protocols.
• The nanoplatform provides a versatile and efficient approach for improving cancer therapy.