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Internet-delivered lifestyle physical activity intervention for cognitive processing speed in multiple sclerosis
Robert W Motl1, Brian M Sandroff2, Ralph H B Benedict3
1Department of Kinesiology and Nutrition, University of Illinois Chicago, 1919 W. Taylor St, Chicago, IL 60612, USA..
Contemporary Clinical Trials
|January 19, 2024
Summary
This study investigates an internet-delivered lifestyle physical activity intervention for multiple sclerosis patients to improve cognitive processing speed and quality of life. The findings aim to provide evidence for effective behavioral interventions in managing MS symptoms.
Area of Science:
- Neuroscience
- Rehabilitation Medicine
- Behavioral Science
Background:
- Multiple sclerosis (MS) often leads to impaired cognitive processing speed (CPS), impacting learning, memory, and quality of life (QOL).
- Lifestyle physical activity (LPA) interventions show promise, but evidence for internet-delivered, theory-based approaches in MS is limited.
Purpose of the Study:
- To evaluate the efficacy of a Social Cognitive Theory-based (SCT), internet-delivered behavioral intervention for improving CPS in individuals with MS.
- To assess the intervention's impact on learning and memory (L/M), symptoms, and QOL.
Main Methods:
- A Phase-II, parallel-group, randomized controlled trial (RCT) involving 300 participants with MS.
- Participants are randomized to a 6-month behavioral intervention or an attention/social contact control group.
- Primary outcome: Symbol Digit Modalities Test (CPS). Secondary outcomes: California Verbal Learning Test-II (L/M), patient-reported outcomes (fatigue, mood, pain, QOL). Tertiary outcome: accelerometry (steps/day).
Main Results:
- Data collection occurs at baseline, 6 months, and 12 months via remote assessments.
- Primary analyses will use intent-to-treat principles with mixed-effects models and logistic regression.
- The study aims to establish a minimal clinically important difference (MCID) for LPA in improving CPS.
Conclusions:
- Successful outcomes will provide Class I evidence for an internet-delivered LPA intervention targeting CPS in MS.
- This intervention has the potential to improve cognitive function and mitigate the negative effects of impaired CPS on other health outcomes in MS patients.
