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Related Concept Videos

Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
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Tumor Immunotherapy01:27

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Stem Cell Culture01:17

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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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Gene Therapy00:59

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Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
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Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Mesenchymal Stem Cells01:19

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Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
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Non-Viral Engineering of Primary Human T Cells via Homology-Mediated End-Joining Targeted Integration of Large DNA Templates
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[Cell therapy in all its forms].

Aurore Dougé1, Christophe Caux2, Jacques-Olivier Bay1

  • 1Service d'oncologie médicale, centre hospitalier universitaire, Clermont-Ferrand, France; EA(UR)7453 CHELTER, université Clermont Auvergne, Clermont-Ferrand, France.

Bulletin Du Cancer
|January 19, 2024
PubMed
Summary
This summary is machine-generated.

Immunotherapy, including adoptive cell therapy, offers new cancer treatments. This review details three main strategies: stem cell transplant, CAR-T, and TCR-T cell therapies, exploring their benefits and drawbacks.

Keywords:
Allo-CSHAllo-HSCTCAR-T cellCell therapyCellule CAR-TCellule TCR-TCytotoxic T cellEffet GvLGvL effectImmunotherapyImmunothérapieLymphocyte T cytotoxiqueTCR-T cellThérapie cellulaire

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Area of Science:

  • Oncology and Immunology
  • Cancer Therapeutics
  • Cellular Therapy

Context:

  • Immunotherapy has transformed cancer treatment for hematologic malignancies and solid tumors.
  • Adoptive cell therapy is a key immunotherapy approach, enhancing antitumor immunity via T lymphocytes.
  • Current research focuses on advancing various immunotherapy modalities.

Purpose:

  • To elucidate the mechanisms of action for three major adoptive cell therapy strategies.
  • To outline the current advantages, limitations, and constraints of these therapies.
  • To provide a comprehensive overview of allogeneic hematopoietic stem cell transplantation, CAR-T cell therapy, and TCR-T cell therapy.

Summary:

  • Adoptive cell therapy involves infusing immune cells to restore antitumor immunity, primarily through T lymphocyte cytotoxicity.
  • Three primary strategies are discussed: allogeneic hematopoietic stem cell transplantation, chimeric antigen receptor T cell (CAR-T) therapy, and T cell receptor (TCR) T cell therapy.
  • The article details the operational principles, benefits, and challenges associated with each of these advanced cancer treatment modalities.

Impact:

  • Offers insights into cutting-edge cancer treatment modalities.
  • Aids clinicians and researchers in understanding the landscape of adoptive cell therapy.
  • Facilitates informed decision-making regarding the application of these revolutionary cancer immunotherapies.