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Effect of Magnesium on Ventricular Extrasystoles in Children

Fahrettin Uysal1, Hasan Turkmen1, Abdusselam Genc1

  • 1Department of Pediatric Cardiology, Faculty of Medicine, Bursa Uludag University, Bursa, Türkiye.

Clinical Pediatrics
|January 20, 2024
PubMed

Insights

Oral magnesium supplementation effectively reduced ventricular extrasystoles (VES) in children. This study suggests magnesium therapy can suppress VES, even with normal serum magnesium levels.

Area of Science:

  • Cardiology
  • Pediatric Cardiology
  • Clinical Nutrition

Background:

  • Magnesium (Mg) is vital for cardiovascular health, and its deficiency is linked to cardiac arrhythmias.
  • Ventricular extrasystoles (VES) are common arrhythmias in children, necessitating effective treatment strategies.

Purpose of the Study:

  • To investigate the efficacy of oral magnesium supplementation in reducing the frequency of VES in pediatric patients.
  • To determine if serum magnesium levels influence the effectiveness of oral magnesium therapy for VES.

Main Methods:

  • A cohort of 42 children with VES and no structural heart disease received oral magnesium supplementation.
  • Data were collected through clinical evaluations, electrocardiography, and 24-hour Holter monitoring before and after supplementation.
  • Serum magnesium levels were assessed pre-treatment.

Main Results:

  • Oral magnesium supplementation significantly decreased the mean 24-hour VES burden from 10.26% ± 4.13% to 6.62% ± 3.88%.
  • No significant correlation was observed between pre-treatment serum magnesium levels and the reduction in VES frequency.
  • The treatment was well-tolerated, with no adverse events reported.

Conclusions:

  • Oral magnesium therapy is an effective intervention for suppressing VES in children, irrespective of baseline serum magnesium levels.
  • Further large-scale, randomized controlled trials are warranted to confirm these findings and establish magnesium's role in managing pediatric arrhythmias.

Keywords:
childrenmagnesiumventricular extrasystole

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