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Breast Cancer Screening and Treatment Clinical Trials Updated for 2023
Imarhia E Enogieru1, Christopher E Comstock2, Lars J Grimm1
1Department of Radiology, Duke University Medical Center, Durham, NC, USA.
Abstract:
There are many active or recently completed breast cancer screening and treatment trials in 2023 that have the potential to fundamentally change the way breast radiologists practice medicine. Breast cancer screening trials may provide evidence to support supplemental screening beyond mammography to include US, contrast-enhanced mammography, and breast MRI. Furthermore, there are multiple efforts to support risk-adaptive screening strategies that would personalize screening modalities, frequencies, and ages of initiation. For breast cancer treatment, aims to reduce overtreatment may provide nonsurgical treatment options for women with low-risk breast cancer. Breast radiologists must be familiar with the study designs, major inclusion and exclusion criteria, and principal endpoints in order to determine when and how the study results should influence clinical care. As multidisciplinary team members, breast radiologists will have major roles in the success or failure of these trials as they transition from research to actual clinical practice.
Insights
New breast cancer trials in 2023 may change screening and treatment. Radiologists should understand these studies to integrate new findings, including risk-adaptive screening and nonsurgical options for low-risk patients.
Area of Science:
- Radiology
- Oncology
- Clinical Trials
Background:
- Numerous breast cancer screening and treatment trials are active or recently completed in 2023.
- These trials have the potential to significantly alter current practices in breast radiology.
Purpose of the Study:
- To inform breast radiologists about pivotal 2023 trials in screening and treatment.
- To highlight the importance of understanding trial designs, criteria, and endpoints for clinical integration.
Main Methods:
- Review of ongoing and recently completed breast cancer clinical trials.
- Analysis of potential impacts on screening modalities (e.g., ultrasound, contrast-enhanced mammography, MRI) and risk-adaptive strategies.
- Examination of treatment trials focusing on reducing overtreatment and exploring nonsurgical options for low-risk breast cancer.
Main Results:
- Screening trials may support supplemental imaging beyond mammography.
- Risk-adaptive screening strategies aim to personalize screening protocols.
- Treatment trials are exploring nonsurgical options for specific patient groups, potentially reducing overtreatment.
Conclusions:
- Breast radiologists must familiarize themselves with trial details to guide clinical practice.
- Radiologists play a crucial role in the successful transition of trial findings into clinical application.
- Understanding these trials is essential for advancing breast cancer care and personalized medicine.
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