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Physiological Evidence and Therapeutic Outcomes of Vitamin D on Cardiovascular Diseases
Abolfazl Zendehdel1, Amir Shakarami2, Ehsan Sekhavati Moghadam3
1Department of Geriatric Medicine, Ziaeian Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Insights
Vitamin D deficiency impacts cardiovascular health, affecting conditions like hypertension and heart failure. While supplementation aims to normalize levels, clinical trial results on its effectiveness show inconsistencies.
Area of Science:
- Endocrinology
- Cardiovascular Medicine
- Nutritional Science
Background:
- Vitamin D hormone regulates physiological functions, including calcium and parathyroid hormone homeostasis.
- Vitamin D deficiency is linked to cardiovascular issues such as hyperlipidemia, atherosclerosis, cardiac inflammation, hypertension, myocarditis, myocardial infarction, and heart failure.
- Existing research demonstrates the role of vitamin D in cardiovascular physiology through animal and human studies.
Purpose of the Study:
- To review the established role of vitamin D in cardiovascular health.
- To summarize recent clinical findings on the effectiveness of vitamin D supplementation for cardiovascular outcomes.
Main Methods:
- Literature review of existing data on vitamin D and cardiovascular health.
- Analysis of recent clinical trial findings concerning vitamin D supplementation.
Main Results:
- Vitamin D deficiency is associated with numerous cardiovascular conditions.
- Clinical trials investigating vitamin D supplementation show variable and sometimes conflicting results regarding its effectiveness.
Conclusions:
- Vitamin D plays a significant role in maintaining cardiovascular health.
- Further research is needed to clarify the precise benefits and optimal strategies for vitamin D supplementation in cardiovascular disease prevention and management.
Abstract:
Vitamin D hormone is an important regulator of various physiological functions, and its deficiency is characterized by an imbalance in parathyroid hormone and calcium homeostasis. The role of vitamin D in cardiovascular physiology is well demonstrated in animal and humanbased studies. In this context, hyperlipidemia, increased atherogenic plaques, cardiac inflammation, hypertension, myocarditis, myocardial infarction, and heart failure are some of the commonest known conditions connected with vitamin D deficiency. Supplementation of vitamin D is recommended to achieve normal serum vitamin D concentrations, nonetheless, in clinical trials often seen discrepancies concerning the supplementation effects and effectiveness. This review summarizes the data on the role of vitamin D in cardiovascular health along with some recent clinical findings regarding the effects of vitamin D supplementation.
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