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Interference with oral theophylline absorption by continuous nasogastric feedings
Therapeutic Drug Monitoring
|January 1, 1986
Summary
Continuous enteral nutrition can interfere with oral medication absorption, leading to ineffective treatment. This case highlights how nasogastric tube feeding may reduce theophylline levels, causing recurrent bronchospasm in patients.
Area of Science:
- Clinical Pharmacy
- Gastroenterology
- Pulmonology
Background:
- Continuous enteral nutrition via nasogastric tubes is vital for malnourished patients with poor oral intake.
- Concurrent oral medication administration can lead to drug malabsorption and treatment failure.
- Theophylline is commonly prescribed for respiratory conditions like bronchospasm.