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Sleep disordered breathing and neurobehavioral deficits in children and adolescents: a systematic review

Weiyu Zhang1, Yubin Shen1, Xiwen Ou1

  • 1Department of Respiratory Medicine and Sleep Lab, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200092, China.

BMC Pediatrics
|January 20, 2024
PubMed

Insights

Sleep disordered breathing (SDB) significantly impacts children's neurobehavioral health. This study found that SDB may account for up to 19.8% of neurobehavioral deficits in children and adolescents.

Area of Science:

  • Pediatric Neurology
  • Sleep Medicine
  • Public Health

Background:

  • Sleep disordered breathing (SDB) is linked to neurobehavioral deficits in children and adolescents.
  • Quantifying the proportion of these deficits attributable to SDB is crucial for public health initiatives.

Approach:

  • A systematic review and meta-analysis were conducted using data from electronic databases.
  • Population attributable fractions (PAFs) were calculated using Levin's and Miettinen's formulas.
  • Prevalence of SDB and risk of SDB-related neurobehavioral deficits were analyzed.

Key Points:

  • SDB prevalence was 11% in the general pediatric population and 25% in neurobehavioral patients.
  • SDB diagnosis increased the risk of subsequent neurobehavioral deficits by approximately threefold (RR 3.24).
  • PAFs indicated that 19.8% (Levin's) or 17.3% (Miettinen's) of neurobehavioral consequences may be attributed to SDB.

Conclusions:

  • A significant proportion of neurobehavioral consequences in children and adolescents may be attributable to SDB.
  • Timely identification and treatment of SDB are essential for managing neurobehavioral impairments.
  • Further longitudinal studies are needed to confirm the SDB-neurobehavioral deficit association.
Abstract

Keywords:
AdolescentsBehavior disordersChildrenMeta-analysisMood disordersPopulation attributable fractionSleep disordered breathing

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