Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Covalently Linked Protein Regulators02:04

Covalently Linked Protein Regulators

6.8K
Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an important role in the function and stability of these proteins. Covalently linked molecules include functional groups, such as methyl, acetyl, and phosphate groups, and also small proteins, such as ubiquitin. There are around 200 different types of covalent regulators that have been identified.
These groups modify specific amino acids in a protein....
6.8K
The Tumor Microenvironment02:17

The Tumor Microenvironment

6.6K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Discharge health education needs and experiences of patients with skeletal-related events from bone metastases: A qualitative study.

PloS one·2026
Same author

The gut-Joint axis: investigating functional gastrointestinal disorders as risk factors for prosthetic joint infections a retrospective case-control study.

Postgraduate medicine·2026
Same author

Posttranslational modifications in regulating Notch signaling pathway and tumor angiogenesis: from molecular mechanisms to therapeutic applications.

Journal of molecular cell biology·2025
Same author

Thyroid metastases from breast cancer: a case report and brief literature review.

Frontiers in oncology·2025
Same author

HDAC Inhibitors Enhance the Chemosensitivity of Osteosarcoma Cells to Etoposide by Suppressing the Hippo/YAP Signaling Pathway.

International journal of molecular sciences·2025
Same author

Activation of T Cell-Intrinsic p53 by Acetylation Elicits Antitumor Immunity to Boost Cancer Immunotherapy.

Cancer discovery·2025

Related Experiment Video

Updated: Jul 5, 2025

Author Spotlight: Evaluation of Protein-Condensate Dynamics in Live Human Cells
06:48

Author Spotlight: Evaluation of Protein-Condensate Dynamics in Live Human Cells

Published on: January 5, 2024

3.6K

Interplay between posttranslational modifications and liquid‒liquid phase separation in tumors.

Xiaojun Yan1, Meng Zhang1, Donglai Wang1

  • 1State Key Laboratory of Common Mechanism Research for Major Diseases & Department of Medical Genetics, Institute of Basic Medical Sciences & School of Basic Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100005, China.

Cancer Letters
|January 21, 2024
PubMed
Summary

Liquid-liquid phase separation (LLPS) regulates cellular processes linked to cancer. Posttranslational modifications (PTMs) critically control LLPS in tumorigenesis and therapy, offering new research avenues.

Keywords:
Intrinsically disordered regions (IDRs)Liquid‒liquid phase separation (LLPS)Posttranslational modifications (PTMs)Tumor

More Related Videos

Quantitative Mass Spectrometric Profiling of Cancer-cell Proteomes Derived From Liquid and Solid Tumors
08:08

Quantitative Mass Spectrometric Profiling of Cancer-cell Proteomes Derived From Liquid and Solid Tumors

Published on: February 27, 2015

16.2K
Isolation of Proximal Fluids to Investigate the Tumor Microenvironment of Pancreatic Adenocarcinoma
05:44

Isolation of Proximal Fluids to Investigate the Tumor Microenvironment of Pancreatic Adenocarcinoma

Published on: November 5, 2020

4.3K

Related Experiment Videos

Last Updated: Jul 5, 2025

Author Spotlight: Evaluation of Protein-Condensate Dynamics in Live Human Cells
06:48

Author Spotlight: Evaluation of Protein-Condensate Dynamics in Live Human Cells

Published on: January 5, 2024

3.6K
Quantitative Mass Spectrometric Profiling of Cancer-cell Proteomes Derived From Liquid and Solid Tumors
08:08

Quantitative Mass Spectrometric Profiling of Cancer-cell Proteomes Derived From Liquid and Solid Tumors

Published on: February 27, 2015

16.2K
Isolation of Proximal Fluids to Investigate the Tumor Microenvironment of Pancreatic Adenocarcinoma
05:44

Isolation of Proximal Fluids to Investigate the Tumor Microenvironment of Pancreatic Adenocarcinoma

Published on: November 5, 2020

4.3K

Area of Science:

  • Cell Biology
  • Biochemistry
  • Cancer Research

Background:

  • Liquid-liquid phase separation (LLPS) is a cellular mechanism for compartmentalizing proteins and nucleic acids into condensates.
  • LLPS plays a role in critical biological processes, including transcriptional regulation, heterochromatin formation, and signal transduction.
  • These processes are implicated in tumor initiation, progression, and response to cancer therapy.

Purpose of the Study:

  • To review the biological functions of LLPS in cancer.
  • To discuss the roles of LLPS in tumor development and treatment.
  • To highlight how posttranslational modifications (PTMs) regulate LLPS in cancer.

Main Methods:

  • Literature review of studies on LLPS in cancer.
  • Analysis of PTMs' impact on LLPS mechanisms.
  • Synthesis of current understanding and future perspectives.

Main Results:

  • LLPS is increasingly recognized for its involvement in cancer-associated biological pathways.
  • PTMs are key regulators of LLPS, influencing its function in both normal and cancerous cells.
  • Understanding PTM-regulated LLPS offers insights into tumor progression and therapeutic strategies.

Conclusions:

  • LLPS is a critical regulator in cancer biology, influencing processes from initiation to treatment response.
  • PTMs dynamically modulate LLPS, presenting significant mechanistic insights into cancer.
  • Further research into PTM-regulated LLPS is essential for advancing cancer diagnostics and therapeutics.