Related Experiment Video
Updated: Jul 5, 2025

Ultrasonography of the Adult Male Urinary Tract for Urinary Functional Testing
Published on: August 14, 2019
Benign Prostatic Hyperplasia and Incident Cardiovascular Disease
Yuta Suzuki1,2, Hidehiro Kaneko1,3, Akira Okada4
1Department of Cardiovascular Medicine, The University of Tokyo.
Benign prostatic hyperplasia (BPH) increases the risk of cardiovascular disease (CVD) in middle-aged men. This nationwide study found BPH is linked to higher risks of myocardial infarction, angina, stroke, heart failure, and atrial fibrillation.
Area of Science:
- Cardiovascular Medicine
- Urology
- Epidemiology
Background:
- Limited data exist on the link between benign prostatic hyperplasia (BPH) and incident cardiovascular disease (CVD).
- Understanding this association is crucial for comprehensive patient care.
Purpose of the Study:
- To investigate the association between BPH and the risk of developing various CVDs.
- To clarify the relationship using a large-scale, nationwide epidemiological database.
Main Methods:
- Retrospective observational cohort study using the JMDC Claims Database (2005-2022).
- Included 2,370,986 men (median age 44 years).
- Assessed risks for myocardial infarction (MI), angina pectoris (AP), stroke, heart failure (HF), and atrial fibrillation (AF).
Main Results:
- BPH was present in 2.1% of participants.
- Increased hazard ratios for BPH were observed for AP (1.31), stroke (1.26), HF (1.21), and AF (1.15).
- The association persisted even in men without obesity, hypertension, diabetes, or dyslipidemia.
Conclusions:
- Benign prostatic hyperplasia is associated with an elevated risk of developing cardiovascular disease in middle-aged men.
- Findings highlight the importance of considering cardiovascular risk in men with BPH.
More Related Videos
08:38Renal Capsule Xenografting and Subcutaneous Pellet Implantation for the Evaluation of Prostate Carcinogenesis and Benign Prostatic Hyperplasia
Published on: August 28, 2013
07:51Hydra, a Computer-Based Platform for Aiding Clinicians in Cardiovascular Analysis and Diagnosis
Published on: September 26, 2018
Related Concept Videos
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
Disorders of the Male Reproductive System
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
Hypertension and Regulation of Blood Pressure
Disorders of the Autonomic Nervous System
Raynaud's disease, also known as Raynaud's...
Adrenergic Antagonists: Pharmacological Actions of β-Receptor Blockers
Cardiovascular Drugs: Classification based on Therapeutic Indications