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Sterically Congested Protecting Group for a Boronyl Group in Iterative Aminations
Takaki Nojiri1, Naoki Tsuchiya1, Takashi Nishikata1
1Graduate School of Science and Engineering, Yamaguchi University, 2-16-1 Tokiwadai, Ube, Yamaguchi, 755-8611, Japan.
Abstract:
In this study, we found that the sterically bulky α-hydroxycarboxamide moiety is a suitable framework for protecting the boronyl group of boron reagents during aminations. Condensation of α-hydroxycarboxamide with ArB(OH)2 produced aryloxazaborolidinone (ArOxB). The reactivity of the C-B bond in ArOxB is easily controlled by the steric and weak electronic effects of the backbone. H2N-(or Br-)ArOxB underwent Chan-Evans-Lam (C-E-L) or Buchwald-Hartwig (B-H) amination with retaining the C-B bond. On the other hand, direct C-E-L amination of ArOxB was also possible in an oxidative atmosphere, in which the C-B bond was activated by CuII species. Our methodology is effective for the precise synthesis of two or more arylamino group substituted arenes.
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