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Robust aortic media adhesion using hydrophobically modified Alaska pollock gelatin-based adhesive for aortic
Temmei Ito1,2, Ryo Mizuta1,2, Shima Ito1,2
1Graduate School of Pure and Applied Sciences, University of Tsukuba, Tsukuba, Japan.
Summary
New gelatin-based adhesives offer improved biocompatibility for treating type-A aortic dissection. These innovative materials effectively bond to aortic tissue, showing promise for surgical repair and reducing risks associated with traditional aldehyde glues.
Area of Science:
- Biomaterials Science
- Cardiovascular Surgery
- Polymer Chemistry
Background:
- Type-A aortic dissection involves aorta media delamination, requiring surgical repair with grafts.
- Current aldehyde-based glues for aortic repair have limited biocompatibility due to aldehyde release.
- There is a need for biocompatible and effective adhesives for aortic dissection repair.
Purpose of the Study:
- To develop and evaluate novel, biocompatible adhesives for type-A aortic dissection repair.
- To investigate the adhesion strength and mechanical properties of hydrophobically modified Alaska pollock gelatin (hm-ApGltn) adhesives.
- To assess the in vivo biocompatibility and degradation of the developed adhesives.
Main Methods:
- Alaska pollock gelatin was modified with alkyl or cholesteryl (Chol) groups to create hm-ApGltns.
- hm-ApGltns were crosslinked with pentaerythritol poly(ethylene glycol) ether tetrasuccinimidyl glutarate.
- Adhesion strength was tested on porcine aortic media with varying modification ratios.
- Mechanical properties (stretchability) and subcutaneous implantation in mice were evaluated.
Main Results:
- Alkyl or Chol group modification significantly enhanced adhesion strength to porcine aortic media.
- Adhesion strength increased with alkyl modification ratios up to ~20 mol%, then decreased.
- The 7.5Chol-ApGltn adhesive demonstrated excellent stretchability, withstanding 25% vertical expansion/contraction cycles.
- Subcutaneous implantation in mice showed no severe inflammation and observed degradation over time.
Conclusions:
- Hydrophobically modified Alaska pollock gelatin (hm-ApGltn) adhesives exhibit superior adhesion and biocompatibility.
- These novel adhesives show potential for treating type-A aortic dissection, offering a safer alternative to aldehyde-based glues.
- Further research may lead to clinical applications of hm-ApGltn in cardiovascular surgery.
