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Related Concept Videos

Raman Spectroscopy Instrumentation: Overview01:26

Raman Spectroscopy Instrumentation: Overview

406
A conventional Raman spectrophotometer includes a laser source, a sample holding system, a wavelength selector, and a detector.
The monochromatic laser source, typically using visible or near-infrared radiation, generates a highly focused beam of light. This light interacts with the molecules of the sample, scattering some of the light. Liquid and gaseous samples are usually tested in ordinary glass capillaries, while solids can be analyzed as powders packed in capillaries or as potassium...
406

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Related Experiment Video

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A Detailed Protocol for Perspiration Monitoring Using a Novel, Small, Wireless Device
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Soft Epidermal Paperfluidics for Sweat Analysis by Ratiometric Raman Spectroscopy.

Ata Golparvar1, Lucie Thenot1, Assim Boukhayma2

  • 1Bio/CMOS Interfaces (BCI) Laboratory, École Polytechnique Fédérale de Lausanne (EPFL), 2000 Neuchatel, Switzerland.

Biosensors
|January 22, 2024
PubMed
Summary
This summary is machine-generated.

This study introduces a novel, wearable sweat sensor integrating paper-based microfluidics and Raman biosensing for efficient digital biomarker analysis. The bioreceptor-free design offers a cost-effective, mass-producible solution for sweat monitoring.

Keywords:
cellulose-based sensorseco-friendlynon-invasiveoptical biosensorsskin-interfaced biosensorssustainable developmentsweat analysissweat losswearable

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Area of Science:

  • Biomedical Engineering
  • Analytical Chemistry
  • Materials Science

Background:

  • Growing demand for non-invasive digital biomarker analysis using bodily fluids like sweat.
  • Need for easily manufactured, efficient soft lab-on-skin devices for sweat analysis.
  • Limitations of current epidermal microfluidic devices in terms of cost and complexity.

Purpose of the Study:

  • To develop and characterize an integrated microfluidic paper-based device (μPAD) with Raman biosensing for sweat analysis.
  • To create a flexible, lightweight, and wearable sweat patch for swift sweat collection and analysis.
  • To demonstrate a bioreceptor-free and plasmonic nanomaterial-free sensing approach for cost-effective and sustainable biomarker quantification.

Main Methods:

  • Integration of μPADs with non-enhanced Raman-scattering-enabled optical biochemical sensing.
  • Fabrication of a thin, flexible, and stretchable opto-paperfluidic sweat patch using sustainable, cost-effective methods.
  • Utilizing wicking properties of porous materials for sweat collection and transportation, enabling chip-free and imaging-less quantification.
  • Ex vivo analysis of sweat urea and lactate levels using synthesized sweat on porcine skin.

Main Results:

  • Demonstrated a novel opto-paperfluidic sweat patch (0.36 mm thin, 0.19 g weight, 3 cm² footprint).
  • Achieved a 5x reduction in biosensing latency compared to state-of-the-art epidermal microfluidics.
  • Successfully quantified sweat urea and lactate levels with a linear dynamic range of 0–100 mmol/L.
  • Validated the device's performance with synthesized sweat containing over 30 analytes on porcine skin.

Conclusions:

  • The developed sweat patch offers a highly efficient, cost-effective, and mass-producible solution for digital biomarker analysis.
  • The bioreceptor-free Raman biosensing approach eliminates the need for complex biorecognition elements and plasmonic nanomaterials.
  • This technology holds significant potential for resource-limited settings and wearable health monitoring applications.