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Updated: Jul 5, 2025

Single Molecule Analysis of Laser Localized Psoralen Adducts
Published on: April 20, 2017
SYNTHETIC APPROACHES TO 4,8-DIMETHYL-4'- (N-PYRIDINIUMMETHYL)- 4',5'-DIHYDROPSORALENS AND THEIR ACTIVITY AGAINST PAM
Marilyn S Whittemore1,2, Ned D Heindel2, Christophe D Guillon2
1Department of Chemistry, Lehigh University, 6 East Packer Avenue, Bethlehem, PA 18015, U. S. A.
Abstract:
Synthetic approaches to novel 4,8-dimethyl-4'-halomethyl-4',5'-dihydropsoralens as synthetic precursors to 4,8-dimethyl-4'-(N-pyridiniummethyl)-4',5'-dihydropsoralens are described. The compounds are potential therapeutic agents for improved psoralen ultraviolet radiation therapy with reduced mutagenicity.
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