Transcolonoscopic spraying formalin solution for hemorrhagic radiation proctitis: a retrospective analysis

Area of Science:

• Gastroenterology
• Oncology
• Endoscopy

Background:

• Radiation proctitis is a common complication following pelvic radiation therapy.
• Rectal bleeding is the most frequent and troublesome symptom of radiation proctitis.
• This study evaluated formalin solution spraying for hemorrhagic radiation proctitis.

Purpose of the Study:

• To assess the efficacy and safety of transcolonoscopic formalin solution application.
• To evaluate treatment outcomes based on radiation injury severity.
• To analyze complication rates associated with the procedure.

Main Methods:

• 37 patients with hemorrhagic radiation proctitis underwent endoscopic formalin application.
• Patients were categorized into three groups based on radiation injury grade.
• Outcomes and adverse events were monitored for over six months.

Main Results:

• An overall response rate of 89.2% was achieved.
• Response rates were 100% for grades 1-2 and 66.7% for grade 3.
• Mild adverse events like anal pain were manageable.

Conclusions:

• Endoscopic formalin application is effective for hemorrhagic radiation proctitis.
• Efficacy is significantly higher in patients with grades 1-2 radiation injury.
• Formalin spraying offers a viable treatment option with manageable side effects.