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Updated: Jul 5, 2025

Ocular Therapeutic Delivery and Advanced Tissue Retrieval in Adult Rats

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Published on: May 23, 2025

Injection-related Visual Compromise.

Alejandra Santiago Díaz¹, José Raúl Montes², Ileana Nieves Martinez¹

¹From Ophthalmology, University of Puerto Rico School of Medicine, San Juan, Puerto Rico.

Plastic and Reconstructive Surgery. Global Open

|January 22, 2024

Summary

Hyaluronic acid (HA) fillers can cause vision complications like double vision. Prompt treatment with hyaluronidase and steroids resolved the issue in one patient, highlighting the need for early intervention.

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Area of Science:

Dermatology
Ophthalmology
Cosmetic Surgery

Background:

The global market for hyaluronic acid (HA)-based dermal fillers is rapidly expanding, offering popular nonsurgical cosmetic solutions.
Despite their widespread use, HA injections carry risks, including serious vascular complications such as central retinal artery occlusion.

Observation:

A 60-year-old woman developed binocular vertical diplopia (double vision) after receiving HA filler injections in her right tear trough.
Clinical examination revealed right hypertropia, indicative of right inferior rectus paresis, likely caused by vascular injury to the infraorbital artery.

Findings:

The patient's double vision resolved completely following prompt administration of hyaluronidase and oral steroids.
This suggests that early intervention can effectively manage specific vascular complications associated with HA fillers.

Implications:

This case underscores the critical importance of recognizing and diagnosing potential ocular complications following HA filler injections.
Timely and appropriate management, including the use of hyaluronidase, is essential to mitigate adverse effects and preserve visual function.