Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

701
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
701
Clot Retraction and Fibrinolysis01:16

Clot Retraction and Fibrinolysis

6.0K
After a fibrin clot is formed, the next step is clot retraction, a vital process facilitated by platelet contractile proteins, such as actin and myosin. These proteins pull the fibrin strands closer together and condense the clot. This action reduces the size of the clot, creating a smaller, denser structure that effectively seals off the damaged vessel. Clot retraction consolidates the clot and helps with wound healing by bringing the edges of the damaged blood vessel closer together.
6.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Latent Accelerated Diffusion-based Deformation Estimation for Real-time Volumetric Imaging.

Physics in medicine and biology·2026
Same author

A WEb-Accessible comprehensiVE platform for automatic vestibular schwannoma segmentation and longitudinal volumetric tracking.

Neuro-oncology advances·2026
Same author

The Combined Effect of Dietary and Behavioral Risk Factors in Gastric Cancer: A Case-Control Study Using a Healthy Lifestyle Index in Fujian, China.

Nutrients·2026
Same author

Mid-range arc therapy for efficient and RBE-robust proton treatment.

Physics in medicine and biology·2026
Same author

Plant-Based Diet Quality and Gastric Cancer Risk: A Case-Control Study in High-Risk Regions of Fujian Province, China.

Food science & nutrition·2026
Same author

Latent category analysis of psychosocial characteristics of gastric cancer patients: an association study with quality of life and survival prognosis.

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·2026
Same journal

Factors Influencing Functional Recovery in People After Chronic Critical Illness During Early Neurological Rehabilitation.

Journal of multidisciplinary healthcare·2026
Same journal

Nutritional Support Strategies for Refeeding Syndrome in ICU Patients: A Review of Current Evidence.

Journal of multidisciplinary healthcare·2026
Same journal

Factors Associated with Length of Stay Among Patients in the Emergency Department of an Indonesian Tertiary Hospital: A Cross-Sectional Study.

Journal of multidisciplinary healthcare·2026
Same journal

Development and Expert Consensus of an Evidence-Based Strategy to Prevent Postoperative Delirium in Malnourished Cancer Patients.

Journal of multidisciplinary healthcare·2026
Same journal

Towards a Sub-Acute Cardiorespiratory Physiotherapy Service Within a Hospital-at-Home Model: A Descriptive Qualitative Study.

Journal of multidisciplinary healthcare·2026
Same journal

Directional Symptom Dependencies in Multiple Sclerosis and Parkinson's Disease: A Comparative Bayesian Network Analysis.

Journal of multidisciplinary healthcare·2026
See all related articles

Related Experiment Video

Updated: Jul 5, 2025

Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation
04:37

Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation

Published on: May 23, 2025

384

CA125-Associated Activated Partial Thromboplastin Time and Thrombin Time Decrease in Patients with Adenomyosis.

Fanchun Yang1, Qingying Wang1, Rui Ma1

  • 1Department of Obstetrics and Gynecology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, People's Republic of China.

Journal of Multidisciplinary Healthcare
|January 22, 2024
PubMed
Summary
This summary is machine-generated.

Adenomyosis patients exhibit altered coagulation, with elevated CA125 linked to shorter thrombin time (TT) and activated partial thromboplastin time (APTT). Early monitoring of these coagulation indicators may help identify hypercoagulability and prevent thrombosis.

Keywords:
APTTCA125TTadenomyosiscoagulation parametershypercoagulability

More Related Videos

Establishing a Mouse Model of Thin Endometrium
05:26

Establishing a Mouse Model of Thin Endometrium

Published on: November 1, 2024

724
Dynamic Multiparameter Platelet Function Assessment Using a Capacitive Biosensor
06:32

Dynamic Multiparameter Platelet Function Assessment Using a Capacitive Biosensor

Published on: May 2, 2025

263

Related Experiment Videos

Last Updated: Jul 5, 2025

Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation
04:37

Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation

Published on: May 23, 2025

384
Establishing a Mouse Model of Thin Endometrium
05:26

Establishing a Mouse Model of Thin Endometrium

Published on: November 1, 2024

724
Dynamic Multiparameter Platelet Function Assessment Using a Capacitive Biosensor
06:32

Dynamic Multiparameter Platelet Function Assessment Using a Capacitive Biosensor

Published on: May 2, 2025

263

Area of Science:

  • Gynecology
  • Hematology
  • Reproductive Medicine

Background:

  • Adenomyosis is associated with a hypercoagulable state.
  • Carbohydrate antigen 125 (CA125) is implicated in adenomyosis-related hypercoagulability and thrombosis.
  • Clarity on CA125's impact on coagulation indicators in adenomyosis is lacking.

Purpose of the Study:

  • To investigate changes in CA125-related coagulation parameters in adenomyosis patients.
  • To identify factors influencing these coagulation changes.

Main Methods:

  • Retrospective observational study involving 200 adenomyosis patients, 240 uterine leiomyoma patients, and 81 cervical intraepithelial neoplasia-III controls.
  • Coagulation parameters were analyzed from clinical blood samples.
  • Multivariate logistic regression and correlation analyses were performed.

Main Results:

  • Adenomyosis patients showed significantly higher CA125 levels compared to controls.
  • Shortened thrombin time (TT) and activated partial thromboplastin time (APTT) were observed in adenomyosis patients.
  • Adenomyosis was independently associated with CA125, APTT, TT, menorrhagia, and dysmenorrhea. APTT and TT negatively correlated with CA125 levels.

Conclusions:

  • Shortened CA125-related APTT and TT suggest potential hypercoagulability in adenomyosis.
  • Early detection of coagulation parameters in patients with elevated CA125, dysmenorrhea, and menorrhagia is clinically significant.
  • Monitoring these indicators may aid in preventing thrombosis in adenomyosis.