Consistency in Standalone Canaloplasty Outcomes Using the iTrack Microcatheter

Area of Science:

• Ophthalmology
• Glaucoma Surgery
• Minimally Invasive Glaucoma Surgery (MIGS)

Background:

• Open-angle glaucoma (OAG) poses a significant challenge in managing intraocular pressure (IOP) and preventing vision loss.
• Medication adherence and efficacy can be problematic for patients with uncontrolled OAG.
• Ab-interno canaloplasty offers a less invasive approach to address OAG by targeting Schlemm's canal.

Purpose of the Study:

• To assess the consistency of outcomes for standalone ab-interno canaloplasty in reducing IOP.
• To evaluate the reduction in glaucoma medication usage after the procedure.
• To analyze these effects over a 12-month follow-up period in patients with uncontrolled OAG.

Main Methods:

• Retrospective analysis of a multicenter case series involving 60 patients (64 eyes) with uncontrolled OAG.
• Patients underwent standalone canaloplasty using the iTrack microcatheter for 360° viscodilation of Schlemm's canal.
• Exclusion of eyes requiring additional glaucoma surgery; analysis focused on IOP and medication reduction per eye.

Main Results:

• At 12 months, 89% of eyes (57/58) achieved reduced IOP.
• Medication reduction was observed in 69% of eyes, with 40% becoming medication-free.
• 78% of eyes showed a ≥20% IOP reduction, and 69% achieved postoperative IOP ≤15 mmHg.

Conclusions:

• Standalone ab-interno canaloplasty demonstrates consistent efficacy in lowering IOP.
• The procedure significantly reduces the need for glaucoma medications.
• This surgical technique is a reliable option for managing uncontrolled open-angle glaucoma.