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Updated: Jul 5, 2025
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Multimodal 3D Printing of Phantoms to Simulate Biological Tissue
Published on: January 11, 2020
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3D printed non-uniform anthropomorphic phantoms for quantitative SPECT
Lovisa Jessen1, Johan Gustafsson2, Michael Ljungberg2
1Medical Radiation Physics, Lund, Lund University, Lund, Sweden. Lovisa.jessen@med.lu.se.
EJNMMI Physics
|January 22, 2024
Summary
This study introduces a 3D printing method for creating realistic phantoms with varied activity distributions, crucial for evaluating quantitative SPECT imaging. The technique successfully produced accurate phantoms, validating its use in SPECT image analysis.
Area of Science:
- Medical Imaging
- 3D Printing Technology
- Radiopharmaceutical Dosimetry
Background:
- Developing anthropomorphic phantoms with non-uniform activity is essential for quantitative SPECT image evaluation.
- A novel 3D printing grid-based method was created to address this need.
Purpose of the Study:
- To characterize a 3D printing grid-based method for creating phantoms.
- To assess the method's ability to generate realistic phantoms with non-uniform activity distributions.
Main Methods:
- Grid structures were characterized using micro-CT imaging and SPECT modulation contrast.
- Kidney and thyroid phantoms were 3D printed using the grid-based technique and filled with radionuclides (177Lu, 99mTc).
- SPECT imaging was performed, and results were compared with Monte Carlo simulations.
Main Results:
- Printing inaccuracies were found to be uniform.
- Linear relationships were observed between fillable-volume fraction (FVF) and modulation contrast.
- Measured and simulated SPECT images showed similar activity distributions, confirming the method's validity.
Conclusions:
- The grid-based 3D printing technique is effective for producing realistic phantoms.
- These phantoms are suitable for evaluating quantitative SPECT imaging methods.
