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Mandibular Gorham-Stout Disease With Implanted Fibular Resorption
Cheng Miao1, Yubin Cao, Chunjie Li
1State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Frontier Innovation Center for Dental Medicine Plus & Department of Head and Neck Oncology, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
The Journal of Craniofacial Surgery
|January 22, 2024
Summary
Gorham-Stout disease, a rare bone disorder, caused progressive osteolysis in the mandible. This case highlights its rare maxillofacial involvement and progression to grafted bone.
Area of Science:
- Oral and Maxillofacial Surgery
- Pathology
- Radiology
Background:
- Gorham-Stout disease is an exceptionally rare condition causing progressive bone loss (osteolysis).
- Its etiology remains unknown, though vascular proliferation is a key pathological feature.
- Maxillofacial involvement is uncommon, with limited case reports.
Observation:
- This report details a unique case of Gorham-Stout disease affecting the mandible.
- The condition initially impacted the alveolar bone.
- It subsequently progressed to involve mandibular marginal branches and a vascularized free fibula graft.
Findings:
- The study documents the extensive progression of Gorham-Stout disease within the mandible.
- It demonstrates the disease's capacity to affect grafted bone tissue.
- Radiological and pathological findings confirmed massive osteolysis.
Implications:
- This case expands the understanding of Gorham-Stout disease's potential manifestations in the maxillofacial region.
- It underscores the challenges in managing this rare condition, especially after reconstructive surgery.
- Further research into the disease's mechanisms is warranted for improved therapeutic strategies.
