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CALR mutation burden in essential thrombocythemia and disease outcome
Paola Guglielmelli1, Natasha Szuber2,3,4, Naseema Gangat5
1Department of Experimental and Clinical Medicine, Center of Research and Innovation of Myeloproliferative Neoplasms, Division of Hematology, Azienda Ospedaliera Universitaria Careggi, Florence, Italy.
Blood
|January 22, 2024
Abstract:
Among 281 patients with essential thrombocythemia and calreticulin (CALR) mutation, we found a variant allele frequency of ≥60% to be associated with significantly shortened myelofibrosis-free survival, mostly apparent with CALR type-1 and CALR type-indeterminate mutations.

