Platelet-Rich Plasma Versus Platelet-Poor Plasma for Treating Facial Photoaging: a Double-Blind Randomized Controlled...

Area of Science:

• Dermatology
• Aesthetic Medicine
• Regenerative Medicine

Background:

• Growing demand for non-invasive anti-aging treatments.
• Increasing interest in autologous platelet-rich plasma (PRP) and platelet-poor plasma (PPP) for facial rejuvenation.
• Limited comparative studies on PRP vs. PPP efficacy for facial aging.

Purpose of the Study:

• To compare the efficacy of PRP and PPP in facial rejuvenation.
• To evaluate the effectiveness of these plasma treatments on different facial aging indicators.

Main Methods:

• Single-center, double-blind, randomized controlled trial.
• Ten participants received 2.5-mL injections of PRP and PPP on contralateral sides of the face.
• Three treatment sessions at 1-month intervals, with outcomes assessed via photographic evaluation and VISIA® system scores.

Main Results:

• Both PRP and PPP significantly improved periocular wrinkles based on Global Aesthetic Improvement Scales and Modified Fitzpatrick Wrinkle Scale.
• No significant difference was observed between PRP and PPP for periocular wrinkles.
• No improvement in nasolabial folds was noted for either treatment; no severe adverse events were reported.

Conclusions:

• PRP and PPP are both effective for treating facial photoaging.
• PRP demonstrated slightly superior efficacy for overall skin condition improvement.
• PPP showed slightly better results for shallow wrinkle improvement, offering valuable evidence for their use in aesthetic procedures.